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High concernFragrance

Musk Ketone

Endocrine disruptorEnvironmental persistence

What it is

A nitromusk synthetic fragrance compound that mimics natural animal musk.

What it does

Base note in perfumes and fragranced products to provide a warm, animalic scent.

Why it’s a concern

Nitromusks are persistent, bioaccumulative organic pollutants. Musk ketone has been detected in human breast milk, adipose tissue, and fish. The EU restricts its use in leave-on products to 1.4% and has reviewed it as a potential endocrine disruptor. Its degradation products include aromatic amines of toxicological concern.

Also known as

4-tert-butyl-2,6-dimethyl-3,5-dinitroacetophenone

CAS numbers

81-14-1

Commonly found in

perfumedetergentcosmetics

Safer alternatives

  • fragrance-free products
  • disclosed natural essential oils

Related chemical families

Synthetic Fragrance

Sources

  • IFRA Standards
  • ECHA Substance Evaluation