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High concernUV filter

Octinoxate

Endocrine disruptorEnvironmental persistence

What it is

A cinnamate-derived UVB absorber, clear oily liquid widely used as a sunscreen active.

What it does

Absorbs UVB radiation to prevent sunburn. Often combined with avobenzone for broad-spectrum coverage.

Why it’s a concern

Octinoxate demonstrates estrogenic activity in rodent uterotrophic assays and has been detected in human urine and breast milk. The 2020 FDA MUsT study confirmed systemic absorption above safety-review thresholds. Like oxybenzone, it is implicated in coral reef damage and is banned in Hawaii and several Pacific jurisdictions.

Also known as

ethylhexyl methoxycinnamateoctyl methoxycinnamateEHMC

CAS numbers

5466-77-3

Commonly found in

sunscreenfoundation with SPFlip balm

Safer alternatives

  • non-nano zinc oxide
  • non-nano titanium dioxide

Sources

  • Matta et al. 2020, JAMA
  • Krause et al. 2012, IJAndrology